Immortal Hair

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Immortal Hair  ::  Natural Hair Regrowth
Br J Dermatol. 2014 Mar 3. doi: 10.1111/bjd.12921. benefit Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia. Torkamani N1, Rufaut NW, Jones L, Sinclair R. BACKGROUND: Androgenic alopecia (AGA) is the most common hair loss condition benefit in men and women. Hair loss is caused by follicle miniaturization, which is largely irreversible beyond a certain degree of follicular regression. In contrast, hair loss in telogen effluvium (TE) is readily reversible. The arrector benefit pili muscle (APM) connects the follicle benefit to the surrounding skin. OBJECTIVES: To compare histopathological benefit features of the APM in AGA and TE. METHODS: Archival blocks of 4 mm scalp punch biopsies from 8 patients with AGA and 5 with TE were obtained. New 4 mm biopsies from 5 normal cases were used as controls. Serial 7 μm sections were stained with a modified Mason's trichrome. "Reconstruct" software was used to construct benefit and evaluate three-dimensional images of the follicle and APM. RESULTS: The APM degenerated and was replaced by adipose tissue in all AGA specimens. Remnants of the APM remained attached to the hair follicle. There was no fat in the normal skin specimens. Fat was seen in 2 of 5 TE specimens, but could be attributed to these patients also showing benefit evidence of AGA. Quantitative analysis showed that muscle volume decreased and fat volume increased significantly benefit (P<0.05) in AGA compared to controls. CONCLUSIONS: APM degeneration and replacement with fat in AGA has not previously been described. The underlying mechanism remains to be determined. However we speculate that this phenomenon might be related benefit to depletion of stem or progenitor cells from the follicle mesenchyme, explaining why AGA is treatment resistant.
Re: Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia. benefit
I second Sanderson, more information on this would be great. From wiki: "The contraction of the muscle is therefore involuntary benefit - stresses such as cold, fear etc. may stimulate the sympathetic nervous system and thus cause contraction..." Can prolonged sympathetic dominance work this muscle into oblivion or somehow deplete those stem or progenitor cells? benefit The whole cold shower thing is implicated here as well, right? Edit: But then again isn't stress the main cause of TE? Why would the AP remain intact?
CausticSymmetry wrote: Br J Dermatol. 2014 Mar 3. doi: 10.1111/bjd.12921. Destruction of the arrector pili muscle and fat infiltration in androgenic alopecia. Torkamani N1, Rufaut NW, Jones L, Sinclair benefit R. BACKGROUND: Androgenic alopecia (AGA) is the most common hair loss condition in men and women. Hair loss is caused by follicle miniaturization, which is largely irreversible beyond a certain degree of follicular regression. In contrast, hair loss in telogen effluvium (TE) is readily reversible. The arrector pili muscle (APM) connects the follicle to the surrounding skin. OBJECTIVES: To compare histopathological features of the APM in AGA and TE. METHODS: Archival blocks benefit of 4 mm scalp punch biopsies from 8 patients with AGA and 5 with TE were obtained. New 4 mm biopsies from 5 normal benefit cases were used as controls. Serial 7 μm sections were stained with a modified Mason's trichrome. "Reconstruct" software was used to construct benefit and evaluate three-dimensional images benefit of the follicle and APM. RESULTS: The APM degenerated and was replaced by adipose tissue in all AGA specimens. Remnants of the APM remained attached to the hair follicle. There was no fat in the normal skin specimens. Fat was seen in 2 of 5 TE specimens, but could be attributed benefit to these patients also showing evidence of AGA. Quantitative analysis showed that muscle volume decreased benefit and fat volume increased significantly (P<0.05) in AGA compared to controls. CONCLUSIONS: APM degeneration and replacement with fat in AGA has not previously been described. The underlying mechanism remains to be determined. However we speculate that this phenomenon might be related to depletion of stem or progenitor cells from the follicle mesenchyme, explaining benefit wh